Not known Details About modafinil dosage
Renal excretion of unchanged modafinil usually accounts for under ten% of the oral dose. Because of this when modafinil is taken by mouth, fewer than 10% of the drug is removed from the body through the urine with out being metabolized with the liver or other organs.
posaconazole will increase the amount or influence of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
Steer clear of coadministration of sensitive CYP3A4 substrates with ivosidenib or substitute with option therapies. If coadministration is unavoidable, observe people for lack of therapeutic influence of such medications.
levoketoconazole will raise the amount or result of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.
Also, your health care professional may be able to tell you about approaches to circumvent or reduce Some Negative effects. Examine along with your health treatment Experienced if any of the following Unwanted side effects proceed or are bothersome or When you've got any questions about them:
modafinil will increase the level or outcome of clobazam by influencing hepatic enzyme CYP2C19 metabolism. Use Warning/Observe. Dosage adjustment could possibly be necessary; CYP2C19 inhibitors may result in increased publicity to N-desmethylclobazam (Energetic metabolite).
eslicarbazepine acetate will raise the level or result of modafinil by impacting hepatic enzyme CYP2C19 metabolism. Use Caution/Check.
Avoid or substitute A different drug for these prescription drugs when attainable. Assess for lack of therapeutic influence if medication has to be coadministered. Modify dose according to prescribing information and facts if wanted.
crofelemer increases amounts of modafinil by more information impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor. Crofelemer has the likely to inhibit CYP3A4 at concentrations envisioned during the intestine; unlikely to inhibit systemically mainly because minimally absorbed.
Watch Closely (one)levoketoconazole will boost the amount or result of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
Other prescription drugs may possibly interact with modafinil, which include prescription and above-the-counter medicines, natural vitamins, and herbal goods. Convey to Every of your respective well being treatment providers about all medicines you utilize now and any medicine you start or prevent making use of.
No precise antidote exists to the toxic outcomes of a PROVIGIL overdose. Such overdoses really should be managed with largely supportive treatment, like cardiovascular monitoring.
Unwanted effects might be prevented or minimized by getting the medication previously from the working day and from other stimulants like coffee or tea.
As an alternative, Check out with the health care provider. When you are employing a drugs for start Management (for example start Handle capsules, implants, shots, patches, vaginal rings, or an IUD), it may not work properly if you are getting modafinil. To help keep from acquiring pregnant, use A further sort of start Handle while you are applying this drugs and for one particular month after your past dose. Other sorts of beginning control involve condoms, diaphragms, or contraceptive foams or jellies. Modafinil may well result in some individuals to experience dizzy, drowsy, have hassle wondering or managing movements, or issues viewing Evidently. Ensure that you know how you respond to this medication prior to deciding to generate, use machines, or do other Positions that need you to definitely be inform, perfectly-coordinated, or capable of think or see nicely. Quit employing this medication and Look at with your physician immediately In case you have the next signs or symptoms though having the drugs: intense actions, stress and anxiety, depression, hallucinations, mania, views of suicide, or other psychological complications. If you have been taking this drugs for a long time or in large doses and you believe you may have become mentally or bodily depending on it, Test with the health practitioner. Some indications of dependence on modafinil are: